Combretastatin D-1

SANC00709

Entry name:

Combretastatin D-1

Formula:

C₁₈H₁₆O₅

Molecular mass:

312.32

ChemSpider ID:

4345840

CAS No.

117709-78-1

2D Image 3D View

SMILES:

O=C4CCc1ccc(O)c(c1)Oc2ccc(cc2)C3OC3CO4

Scaffold SMILES:

c1ccccc1
O=C1CCc2cccc(c2)Oc2ccc(cc2)C2OC2CO1

References

Pettit et al. (1988) Antineoplastic agents. 160. Isolation and structure of combretastatin D-1: a cell growth inhibitory macrocyclic lactone from Combretum caffrum

Classifications

Macrocyclic lactone

Lignan lactones (Classyfire)

Other Names

3,6,15-Trioxatetracyclo[14.2.2.110,14.02,4]Heneicosa-10,12,14(21),16,18,19-Hexaen-7-One, 13-Hydroxy-, [2S-(2R*,4S*)]-

(-)-Combretastatin D1

Source Organisms

Combretum caffrum

Compound Uses

P-388 lymphocytic leukemia (PS) cell line growth inhibition

Cytostatic