SANC00708



Combretastatin A-1




C18H20O6




332.35




4572839




109971-63-3




2D Image 3D View


    • Oc1c(O)c(O[CH3])ccc1/C=C\c2cc(O[CH3])c(O[CH3])c(O[CH3])c2

    c1ccccc1
    C(=Cc1ccccc1)c1ccccc1



  • Odlo et al. (2006) Synthesis of combretastatins A-1 and B-1

  • Pettit et al. (1987) Antineoplastic agents. Part 123. Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum

  • Beutler et al. (2012) The National Cancer Institute and Natural Product-Based Drug Discovery in Africa


  • cis-Stilbene

  • Stilbenes (Classyfire)


  • 1,2-Benzenediol, 3-Methoxy-6-[2-(3,4,5-Trimethoxyphenyl)Ethenyl]-, (Z)-
  • Oxi 4500


  • Combretum caffrum

  • Antineoplastic
  • Inhibit microtubule assembly
  • Inhibit binding of colchicine to tubulin
  • Cytotoxic
  • Antitumor
  • Antimitotic
  • Antiangiogenic
  • Anticancer