SANC00177



Spongiostatin 4





C61H93ClO20









153745-94-9



SMILES:

Cl/C(=C)/C=C/[C@H](O)C/C(=C)C[C@H]3OC4[C@@H](O)[C@@]7(O)O[C@@H](CCC\C=C/[C@H]6O[C@]1(OC(C[C@@H](OC)C1)CC(=O)[C@@H](C)[C@H](O)[C@H](\C(=C)C[C@H]5O[C@]2(OC(C[C@@H](OC(=O)C)C2)CC(=O)O[C@@H]([C@@H]3O)[C@H]4C)C[C@@](O)(C)C5)C)C[C@H](O)C6)[C@@H](C)[C@H](O)C7





References

  • Pettit et al. (1993) Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera (Porifera)

  • Classifications

  • Polyketide

  • Other Names

  • 15-Tritetracontene-27,43-Dione, 39-(Acetyloxy)-1-[(4S,5E)-7-Chloro-4-Hydroxy-2-Methylene-5,7-Octadien-1-Yl]-2,6,7,9,19,29,35-Heptahydroxy-23-Methoxy-4,10,28,30,35-Pentamethyl-31-Methylene-1,3,11,17,21,33,41-Heptaoxy-, (1R,2R,3R,4S,5R,6S,7R,9S,10R,11R,15Z,
  • 8,12,45,46,47,48,50-Heptaoxaheptacyclo[39.3.1.11,5.19,13.115,19.125,29.129,33]Pentacont-23-Ene-7,35-Dione, 3-(Acetyloxy)-11-(7-Chloro-4-Hydroxy-2-Methylene-5,7-Octadienyl)-10,14,15,17,27,37,43-Heptahydroxy-31-Methoxy-18,36,38,43,49-Pentamethyl-39-Methylen
  • 8,12,45,46,47,48,50-Heptaoxaheptacyclo[39.3.1.11,5.19,13.115,19.125,29.129,33]Pentacont-23-Ene-7,35-Dione, 3-(Acetyloxy)-11-[(4S,5E)-7-Chloro-4-Hydroxy-2-Methylene-5,7-Octadienyl]-10,14,15,17,27,37,43-Heptahydroxy-31-Methoxy-18,36,38,43,49-Pentamethyl-39-
  • Cinachyrolide A
  • (1R,3R,9R,10R,11R,14R,15S,17R,18S,19S,23Z,25S,27R,29R,31R,36S,37R,38S,41R,43R,49S)-11-[(4R,5E)-7-Chloro-4-Hydroxy-2-Methylene-5,7-Octadien-1Yl]-10,14,15,17,27,37,43-Heptahydroxy-31-Methoxy-18,36,38,4 3,49-Pentamethyl-39-Methylene-7,35-Dioxo-8,12,45,46,47,
  • Spongistatin 4

  • Source Organisms

  • Spirastrella spinispirulifera (Porifera)

    Compound Uses

  • Anticancer activity